میزان شیوع سرمی عفونت با مایکوپلاسما پنومونیه در بیماران مبتلا به سندرم حاد کرونری

Abstract Background &　Aims: Cardiovascular diseases are the most important causes of death worldwide. There are a lot of different risk factors that increase the susceptibility of patients to cardiovascular disorders. With regard to the possible role of M. pneumoniae infection in triggering and progress of cardiovascular diseases, this study was designed to determine the seroprevalence of antibodies against M. pneumoniae in patients with acute coronary syndrome in Urmia. Materials & Methods: This Case-Control study was conducted by collecting patients’ data by questionnaire, studying patients’ records and laboratory tests. Serum samples were collected from 40 patients with acute coronary syndrome and 44 patients in eye ward matched for age and sex as case and control group, respectively. The levels of serum triglycerides, cholesterol, fasting blood sugar and IgG and IgM antibodies against M. pneumonia was measured and results were analyzed with T- statistical test. Results: There are no significant differences between the mean of age, sex, smoking history and the level of fasting blood sugar, cholesterol, triglycerides and M. pneumonia IgG and IgM antibodies in the case and control groups but there is a significant difference in the mean of the white blood cell counts that was higher in patients. Seroprevalence of IgG was 62.44% and 63.29%in case and control groups respectively and in both groups it was higher in men in compare with women. Positive IgM antibody against M. pneumonia was not detected in both control and test groups. Conclusion: Although high prevalence of infection with M. pneumoniae was found in subjects but its role in increasing the risk of developing acute coronary syndrome was not confirmed. SOURCE: URMIA MED J 2016: 26(10): 843 ISSN: 1027-3727